About our group
The Compound Library of the Institute of Organic Chemistry and Biochemistry (IOCB Prague) presents its own collection of small molecules synthesized at the IOCB Prague. This exceptional library contains diverse and unique chemical scaffolds that are usually missing from commercial libraries, including natural compounds, steroids, peptides, peptidomimetics, and nucleoside and nucleotide analogues, with special emphasis on the latter two groups.
Many of the compounds in the library were developed as part of medicinal chemistry efforts and have been proposed as potential drugs targeting pharmaceutically relevant pathways. Their inherent drug-likeness is evidenced by several FDA-approved therapeutics originating from IOCB Prague, including tenofovir (a widely used HIV and HBV reverse transcriptase inhibitor), adefovir (HBV reverse transcriptase inhibitor), and cidofovir (treatment for retinitis - cytomegalovirus infection of the retina).
In addition to solid-phase storage, the library offers DMSO solutions in 384–well and 1536–well plates, prepared for efficient low-content biochemical screening. These solutions are optimized for direct use in assays, eliminating the need for additional pipetting, saving time and preserving valuable compounds.
The IOCB Compound Library provides researchers with unparalleled access to innovative molecules and compounds with clinical impact, linking basic science with translational applications.
Contact us to use the IOCB Compound Library for your research or drug discovery initiatives.
